A report on sickle cell anemia causes and effects on the human body

They also are at higher risk for: Miscarriages Small-for-date or underweight babies Mental health As in other chronic diseases, people who have sickle cell disease may feel sad and frustrated at times. Sometimes they become depressed. People who have sickle cell disease may also have trouble coping with pain and fatigue, as well as with frequent medical visits and hospitalizations.

A report on sickle cell anemia causes and effects on the human body

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ShareCompartir Only in some individuals do malaria episodes progress to severe life-threatening disease, while in the majority the episodes are self-limiting.

This is partly because of host genetic factors such as the sickle cell gene. The sickle cell gene is caused by a single amino acid mutation valine instead of glutamate at the 6th position in the beta chain of the hemoglobin gene. Inheritance of this mutated gene from both parents leads to sickle cell disease and people with this disease have shorter life expectancy.

On the contrary, individuals who are carriers for the sickle cell disease with one sickle gene and one normal hemoglobin gene, also known as sickle cell trait have some protective advantage against malaria.

A report on sickle cell anemia causes and effects on the human body

As a result, the frequencies of sickle cell carriers are high in malaria-endemic areas. Most earlier studies of the relationship between sickle cell trait and malaria were cross-sectional, and therefore some important data relevant to the protective effects of sickle cell trait were missing.

Most of this protection occurs between months of life, before the onset of clinical immunity in areas with intense transmission of malaria. Those who had the sickle cell trait HbAS had a slight survival advantage over those without any sickle cell genes HbAAwith children with sickle cell disease HbSS faring the worst.

Get Email Updates To receive email updates about this page, enter your email address:What causes sickle cell disease? Sickle cell is an inherited disease caused by a defect in a gene.

A person will be born with sickle cell disease only if two genes are inherited—one from the mother and one from the father.

Sickle Cell Crisis: Symptoms, Causes, Treatment, Prevention

A person who inherits just one gene is healthy and said to be a "carrier" of the disease. Sickle cell disease is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen.

Hemoglobin S changes the red blood cells. The red blood cells become fragile and shaped like crescents or sickles. The abdominal and chest pain experienced by someone with sickle cell anemia is caused by arteries that have become obstructed by a buildup of sickle cells.

If sickle cells cause spleen damage, the body may become more prone to infection.


Sickle cell anemia can also damage blood vessels in the eyes, decreasing vision. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle cell disease: MedlinePlus Medical Encyclopedia View Full Essay Words:

The overall incidence of SCD is eight out of , people. This anemia is what gives the disease its commonly known name - sickle cell anemia. The sickle cells also block the flow of blood through vessels, resulting in lung tissue damage that causes acute chest syndrome, pain episodes, stroke and priapism (painful, prolonged erection).

Heterozygous condition. Most common form of sickle cell disease in the US, pt is a carrier but has no symptoms unless stressed by severe hypoxia. about 40% of their hemoglobin is hemoglobin S.

How does sickle cell anemia affect the body? | Sickle Cell Disease - Sharecare