An introduction to the genetics the human genome project

Human Genes Italia Human Genome:

An introduction to the genetics the human genome project

Each of our cells contains the same complement of DNA constituting the human genome Figure Encoded in the DNA sequence are fundamental determinants of those mental capacities—learning, language, memory—essential to human culture.

Encoded there as well are the mutations and variations that cause or increase susceptibility to many diseases responsible for much human suffering.

Unprecedented advances in molecular and cellular biology, in biochemistry, in genetics, and in structural biology—occurring at an accelerating rate over the past decade—define this as a unique and opportune moment in our history: For the first time we can envision obtaining easy access to the complete sequence of the 3 billion nucleotides in human DNA and deciphering much of the information contained therein.

Converging developments in recombinant DNA technology and genetics make obtaining a complete ordered DNA clone collection indexed to the human genetic linkage map a realistic immediate goal.

Even determination of the complete nucleotide sequence is attainable, although ambitious. The DNA in the human genome is remarkably stable, as it must be to provide a reliable blueprint for building a new organism.

For this reason, obtaining complete genetic linkage and physical maps and deciphering the sequence will provide a permanent base of knowledge concerning all human beings—a base whose utility for all activities of biology and medicine will increase with future analysis, research, and experimentation.

Even the complete sequence of DNA in the human genome will not by itself explain human biology. It will, however, serve as a great resource, an essential data bank, facilitating future research in mammalian biology and medicine.

An introduction to the genetics the human genome project

Humans, like all living organisms, are composed largely of proteins. For humans these are roughly estimated to be ofdifferent kinds. In general, each gene codes for the production of a single protein, and a gene and its protein can be related to each other by means of the genetic code.

Therefore, scientists will be able to turn to the DNA sequence of the human genome and obtain detailed information on both the structure and function of any gene or protein of interest.

In addition, all genes and proteins will be classified into large family groups that provide valuable clues to their functions. In this way, many previously unknown human genes and proteins will become available for biochemical, physiological, and medical studies.

The knowledge gained will have a major impact on health care and disease prevention; it will also raise challenging issues regarding rational, wise, and ethical uses of science and technology. Each DNA strand is composed of four different units, called nucleotides, that are linked end to end to form a long chain Figure These four nucleotides are symbolized as A, G, C, and T, which stand for the four bases—adenine, guanine, cytosine, and thymine—that are parts of the nucleotides.

One DNA molecule, which together with some associated proteins constitutes a chromosome, differs from another in its length and in the order of its nucleotides. Each DNA molecule contains many genes, which are its functional units.

These genes are arranged in a defined order along the DNA molecule. Most genes code for protein molecules—enzymes or structural elements—that determine the characteristics of a cell.

In bacteria, the coding sequences of a gene—are continuous strings of nucleotides, but in mammals the coding segments in a gene called exons are generally separated from one another by noncoding segments called introns Figure Often each exon will encode a different structural region or domain of a larger protein molecule.

Many exons have been found to be part of a family of related coding sequences that are used in the construction of many different genes Doolittle et al. Because of the many introns in mammalian genes, a single gene is often more than than 10, nucleotides long, and genes that spannucleotides are not uncommon Table Figure Two ways of representing the DNA double helix.

Genomes, Genes, and Genomic Maps

Diagrams are of a very short section of the DNA molecule in each chromosome. The human genome contains about million times the amount of DNA shown. The two strands of the DNA double helix run in opposite more Figure The nucleotides that form a DNA molecule. A Specific hydrogen bond interactions between G and C and between A and T bases generate complementary nucleotide pairs that is, G always bonds with C and A always bonds with T.

Science behind the HGP

A haploid human genome contains more Figure How genes are expressed in human cells. Each gene can specify the synthesis of a particular protein.

An introduction to the genetics the human genome project

Whether a gene is off or on depends on signals that act on the regulatory region of the gene.A project to map and sequence the human genome has many different components. In the following sections of this report, we examine implications for medicine and science (Chapter 3), mapping (Chapter 4), sequencing (Chapter 5), data handling and analysis (Chapter 6), implementation and management strategies (Chapter 7), and commercial.

Goals of the Human Genome Project The primary goal of the Human Genome Project was to sequence the 3 billion base pairs that make up human DNA.

From the sequence, the 20, to 25, estimated human genes could be identified. Simply put, the human genome is a set of human genetic information that is stored as DNA sequences.

We have what is called the haploid human genome and the diploid human genome. The haploid human genome can be found in the egg and sperm cells. Research shows that this genome has about three billion DNA base pairs. The Human Genome Is Composed of 24 Different Types of DNA Molecules. Human DNA is packaged into physically separate units called chromosomes.

Humans are diploid organisms, containing two sets of genetic information, one set inherited from the mother and one from the father. Sep 04,  · The Human Genome Project was an international research effort to determine the sequence of the human genome and identify the genes that it contains.

The Project was coordinated by the National Institutes of . The Human Genome Project (HGP) was one of the great feats of exploration in history - an inward voyage of discovery rather than an outward exploration of the planet or the cosmos; an international research effort to sequence and map all of the genes - together known as the genome - of members of our species, Homo sapiens.

Genome - Wikipedia